In this #ISSNAFStory, Barbara Rosario interviews Professor Alessandro Sette, newly appointed to the ISSNAF Board. Prof. Sette discusses his plans to enhance the board’s geographical diversity and scientific expertise while also focusing on increasing funding and fostering global collaborations.  He also provides updates on his research, emphasizing the ongoing need for vigilance in the post-COVID era. While the pandemic has subsided, the virus remains active, making vaccines essential. Prof. Sette’s lab is exploring T-cell responses to various viral families to better anticipate future pandemics, such as avian flu and monkeypox. He also highlights the resurgence of diseases like pertussis following COVID-19 lockdowns and addresses global pharmaceutical readiness, stressing the importance of equitable vaccine development and distribution, particularly in underserved regions.