Daniele Simoneschi

Daniele was born in Rome, Italy, where he graduated from high school (Liceo Scientifico) and studied music at the Santa Cecilia Music Conservatory. In 2009, Daniele decided to move to the United States where he received a Chairman Award Scholarship from Manhattanville College, graduating first in his class (valedictorian) with a major in biochemistry and two minors: music and mathematics. Upon the completion of his undergraduate studies, Daniele joined the laboratory of Dr. Michele Pagano at the New York University Grossman School of Medicine, where he obtained his Ph.D. in 2020. As a graduate student, Daniele focused on the molecular and cellular mechanisms by which cullin-RING ubiquitin ligases (CRLs) regulate the execution of the cell-division cycle. Specifically, Daniele established that the tumor suppressor AMBRA1 acts as a CRL4 substrate receptor that dictates the specificity towards phosphorylated D-type cyclins during cell-cycle progression, and demonstrated that the deregulation of this pathway contributes to the pathogenesis of diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma in the United States and worldwide. To explore novel oncogenic pathways regulated by CRLs, Daniele first served as a Senior Research Coordinator in the laboratory of Dr. Michele Pagano, and was subsequently appointed to the position of faculty member in the Department of Biochemistry and Molecular Pharmacology at the New York University Grossman School of Medicine, where he currently serves as a Research Assistant Professor